A Phase 1 Trial of SHR3680 in Subjects With Metastatic Castration-Resistant Prostate Cancer as Monotherapy

Uncategorized

A Phase 1 Trial of SHR3680 With or Without SHR3162 in Subjects With Metastatic Castration-Resistant Prostate Cancer

Condition: Neoplasm, Prostate Cancer

Intervention:

  • Drug: SHR3680; SHR3162

Purpose: This is a multicenter, dose-escalation/expansion phase 1 trial to evaluate the safety, tolerability and efficacy of SHR3680 with or without SHR3162 given orally to subjects with metastatic castration-resistant prostate cancer (mCRPC).

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT02747342

Sponsor: Atridia Pty Ltd.

Primary Outcome Measures:

  • Measure: Maximum tolerated dose (MTD)
  • Time Frame: 4 weeks
  • Safety Issue:
  • Measure: Recommended Phase 2 doses (RP2Ds)
  • Time Frame: 24 months
  • Safety Issue:

Secondary Outcome Measures:

  • Measure: Number of participants with treatment-emergent adverse events
  • Time Frame: 24 months
  • Safety Issue:
  • Measure: The AUC of SHR3680 and SHR3162 (area under the curve)
  • Time Frame: 4 weeks
  • Safety Issue:
  • Measure: The cMax (peak plasma concentration) of SHR3680 and SHR3162
  • Time Frame: 4 weeks
  • Safety Issue:
  • Measure: PSA reduction
  • Time Frame: 12 weeks
  • Safety Issue:
  • Measure: PSA progression
  • Time Frame: 24 months
  • Safety Issue:
  • Measure: Objective response rate (ORR)
  • Time Frame: 24 months
  • Safety Issue:
  • Measure: Radiological progression-free survival (PFS)
  • Time Frame: 24 months
  • Safety Issue:

Estimated Enrollment: 51

Study Start Date: September 2016

Phase: Phase 1

Eligibility:

  • Age: minimum 18 Years maximum N/A
  • Gender: Male

Inclusion Criteria:

  • 1. Male 18 years and older 2. Ability to understand the purposes and risks of the trial and his/her signed informed consent form approved by the HREC of the trial site, which must be obtained before entering the trial 3. Histologically or cytologically confirmed adenocarcinoma of the prostate without neuroendocrine differentiation or small cell features 4. For patients who have not had an orchiectomy, there must be a plan to maintain effective GnRH-analogue therapy for the duration of the trial 5. Serum testosterone level < 1.7 nmol/L (50 ng/dL) at the screening visit 6. Ongoing androgen deprivation therapy with a gonadotropin releasing hormone (GnRH) analogue or orchiectomy (i.e., surgical or medical castration) 7. Progressive disease by PSA or imaging after docetaxel-based chemotherapy or abiraterone in the setting of medical or surgical castration. Prior enzalutamide is allowed as long as patients had a PSA response >50% or were treated for at least 6 months. Disease progression for study entry is defined by one or more of the following three criteria:
  • PSA progression defined by a minimum of three rising PSA levels with an interval of ≥ 1 week between each determination. The PSA value at the Screening visit should be ≥2 μg/L (2 ng/mL)
  • Soft tissue disease progression defined by RECIST (Appendix A)
  • Bone disease progression defined by two or more new lesions on the bone scan 8. ECOG performance status of 0 or 1 9. Life expectancy of at least 6 months 10. Able to swallow the study drug and comply with study requirements 11. Acceptable liver function defined as:
  • Total bilirubin ≤ 1.5 times the upper limit of normal range (ULN)
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 times ULN; however, ≤ 5 times ULN in a subject who has liver metastases or has been treated with biliary drainage 12. Acceptable renal function defined below: • Serum creatinine ≤ 1.5 times ULN 13. Acceptable hematologic status (without hematologic support including hematopoietic factor, blood transfusion) defined below:
  • Absolute neutrophil count (ANC) ≥ 1,500/μL
  • Platelet count ≥ 100,000/μL
  • Hemoglobin ≥ 9.0 g/dL

Exclusion Criteria:

  1. Treatment with AR antagonists (enzalutamide, bicalutamide, flutamide, nilutamide), 5-α reductase inhibitors (finasteride, dutasteride), estrogens, or chemotherapy within 4 weeks of enrollment (day 1 visit) or plans to initiate treatment with any of these drugs during the study. Ongoing therapy with bisphosphonates or Rank Ligand inhibitors are acceptable.
  2. Prior treatment with a PARP inhibitor or have plans to initiate treatment with a PARP inhibitor during the study (only apply to subjects participating in Part 2b)
  3. Treatment with therapeutic immunizations for prostate cancer (e.g., PROVENGE®) or plans to initiate treatment with any of these therapies during the study
  4. Metastases in the brain or active epidural disease (Note: patients with treated for epidural disease are allowed to enter the trial)
  5. Use of herbal products that may decrease PSA levels (e.g., saw palmetto) or systemic corticosteroids greater than the equivalent of 10 mg of prednisone/prednisolone per day within 4 weeks of enrollment (day 1 visit) or plans to initiate treatment with any of these therapies during the study
  6. History of another malignancy within the previous 5 years other than curatively treated non-melanomatous skin cancer
  7. Radiation therapy within 3 weeks (if single fraction of radiotherapy, then a 1-week gap is allowable) and radionuclide therapy within 8 weeks of enrollment (Day 1 visit). Any radiotherapy-related AE ＞ Grade 1 before the start of study treatment.
  8. Have used or plan to use from 30 days prior to enrollment (day 1 visit) through to the end of the study medications known to lower the seizure threshold or prolong the QT-interval (described in Appendix I)
  9. Cardiac disease with New York Heart Association (NYHA) Class III or IV, including congestive heart failure, myocardial infarction within 6 months prior to the trial entry, unstable arrhythmia, or symptomatic peripheral arterial vascular disease
  10. Severe concurrent disease, infection, or co-morbidity that, in the judgment of the investigator, would make the patient inappropriate for enrollment
  11. History of seizure, including any febrile seizure, loss of consciousness, or transient ischemic attack within 12 months of enrollment (day 1 visit), or any condition that may pre-dispose to seizure (e.g., prior stroke, brain arteriovenous malformation, head trauma with loss of consciousness requiring hospitalization)
  12. Use of an investigational agent within 4 weeks of enrollment or plans to initiate treatment with an investigational agent during the study
  13. Major surgery, other than diagnostic surgery, within 4 weeks prior to trial entry, without complete recovery
  14. Gastrointestinal disorder affecting absorption (e.g., gastrectomy, active peptic ulcer disease within the last 3 months)
  15. Structurally unstable bone lesions suggesting impending fracture

Contact:

  • Kathy You, MD, PhD
  • +61 02 9299 0433

Locations:

  • Border Medical Oncology
  • Albury New South Wales 2640 Australia
  • Chris O’Brien Lifehouse
  • Camperdown New South Wales 2050 Australia
  • St George Hospital
  • Kogarah New South Wales 2217 Australia
  • Liverpool Hospital
  • Liverpool New South Wales 2170 Australia
  • Westmead Hospital
  • Sydney New South Wales 2145 Australia
  • Icon Cancer Centre
  • South Brisbane Queensland 4101 Australia

View trial on ClinicalTrials.gov

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