Evaluation of a Promising New Combination of Protein Kinase Inhibitors on Organotypic Cultures of Human Renal Tumors

Condition: Kidney Cancer


  • Combination Product: CK2 and ATM inhibitors serine/ threonin Kinase combination
  • Drug: Sunitinib
  • Drug: Pazopanib
  • Drug: Temsirolimus

Purpose: The investigators objective is to test the combination directly on organotypic cultures of tumors from patients after their excision in the Department of Urology and Renal Transplantation of the University Hospital of Grenoble and to compare their efficacy with that of currently selected treatments in the clinic. The population targeted by the combination for use in clinical practice is patients with metastatic clear cell renal cell carcinoma. Current treatments for these patients are Sunitinib, Pazopanib and Temsirolimus.

Study Type: Interventional

Clinical Trials Identifier NCT 8-digits: NCT03571438

Sponsor: University Hospital, Grenoble

Primary Outcome Measures:

  • Measure: Incidence of cell death on organotypic cultures of human renal tumors (Efficacy)
  • Time Frame: after the treatment period (between 48 and 96 hours)
  • Safety Issue:

Estimated Enrollment: 100

Study Start Date: October 16, 2017


  • Age: minimum 18 Years maximum N/A
  • Gender: All

Inclusion Criteria:

  • major patient treated at the University Hospital of Grenoble for a renal tumor with suspected or confirmed malignancy.This includes non-metastatic patients undergoing renal lumpectomy, partial nephrectomy or total nephrectomy, as well as metastatic or locally advanced cancer patients undergoing cytoreductive surgery who are eligible for medical treatment at the same time

Exclusion Criteria:

  • Contaminated patients with HIV and /or HBV (hepatitis B virus) and / or HCV (hepatitis C virus) positive serology.
  • Absence or withdrawal of the informed consent of the patient.
  • Tumors smaller than 2 cm on preoperative imaging


  • Jean-Luc Descotes, PU-PH
  • +33 (0)4 76 76 59 22


  • Grenoble Alps Hospital
  • Grenoble 38043 France

View trial on ClinicalTrials.gov