(UroToday.com) In patients with muscle-invasive bladder cancer, pre-operative staging is typically performed with computed tomography. Prior work has demonstrated that in patients without clinical evidence of nodal disease based on conventional imaging, the use of fluorodeoxyglucose-positron emission tomography (FDG-PET)/computed tomography (CT) prior to neoadjuvant chemotherapy and radical cystectomy (RC) or RC alone has limited utility. In a podium presentation at the American Urologic Association (AUA) 2020 Virtual Annual Meeting, Laura Marandino, MD, Andrea Necchi, MD, and colleagues examined a secondary analysis of their prior study specifically aimed at evaluating the role of PET/CT in lymph node (LN) involvement assessment.