(UroToday.com) The vast majority of patients who are newly diagnosed with Renal Cell Carcinoma (RCC) have localized disease (~75%). This proportion has continued to rise with the increasing utilization of cross-sectional imaging in the primary care and emergency department contexts. For patients who are fit for surgery, surgical resection (either via partial or radical nephrectomy) remains the standard of care for patients diagnosed with localized RCC.