(UroToday.com) At the European Association of Urology (EAU) Virtual 2020 meeting, Dr. Nicolas Mottet, chair of the EAU Guidelines prostate cancer panel, summarized the guidelines for recurrence after radical prostatectomy. Dr. Mottet notes that there is a major difference between prostate-specific antigen (PSA) relapse (any PSA rise following an undetectable level) and a clinically significant PSA rise, which is the best predictor for further metastases (ie. post external beam radiation therapy (EBRT) nadir PSA + 2 ng/mL). The EAU definition after radical prostatectomy is thus a PSA > 0.4 ng/mL and rising, which is a clinically relevant threshold, but is not the threshold to define a relapse and is not the threshold to consider salvage treatment.