(UroToday.com) In this debate, a clinical case of a 65-year-old gentleman who was diagnosed with prostate cancer Gleason grade group 2 on biopsy was presented by Giorgio Gandaglia, MD. The patient underwent robotic-assisted radical prostatectomy, demonstrating pT3a, Gleason grade group 4 with negative margins on final pathology, with no lymph node dissection performed. The first postoperative prostate-specific antigen (PSA) was undetectable, but later, PSA started to rise from 0.25 to 0.65 with a PSA doubling time of 1.4 months. The patient received salvage radiotherapy to the prostatic fossa and pelvic lymph nodes + concomitant androgen deprivation therapy (ADT) for 36 months.