(UroToday.com) The European Multidisciplinary Congress on Urological Cancers (EMUC) 2020 virtual meeting featured a discussion of nanoparticles in the Fragments of Imaging session by Dr. Jelle Barentsz. Dr. Barentsz notes that according to the European Association of Urology (EAU) guidelines, pelvic lymph node dissection is the gold-standard for lymph node staging, however, 13% of positive lymph nodes are not detected by pelvic lymph node dissection. According to Dr. Barentsz, the reason for the missed lymph node detection is secondary to surgeons looking for small (<4 mm) lymph nodes deep in the pelvis or higher up in the peri-aortic regions. Because of these nuances and in an effort to improve detection, there is a role for lymph node imaging in these high-risk prostate cancer patients. According to Dr. Barentsz, 68Ga-PSMA PET/CT has a poor role in lymph node staging, detecting microscopic disease in only ~9% of high risk patients, secondary to an inability to detect lymph node metastasis when the positive lymph node is <4.0 mm.