(UroToday.com) The European Multidisciplinary Congress on Urological Cancers 2020 virtual meeting featured a session on oligometastatic disease in genitourinary cancers including a presentation by Dr. Steven Joniau discussing the regional treatment of metastases. The rationale for treatment of the primary tumor and metastases in oligometastatic prostate cancer is to “break the chain” whereby aggressive local treatment halts the premetastatic niche and avoids further metastases. Furthermore, efficient treatment of metastases may also stop further metastatic spread and cross-talk with other micrometastases. With regard to oligometastatic disease, the “seek and destroy” method suggests that early and accurate detection of oligometastases provides an opportunity for metastasis-directed treatment with surgery or stereotactic body radiation therapy (SBRT).