(UroToday.com) The EUO lecture at the 2021 European Association of Urology (EAU) Section of Oncological Urology (ESOU) virtual annual meeting was given by Dr. Thomas Powles, a medical oncologist from London discussing the systemic treatment of metastatic renal cell carcinoma. There have been exciting advances in the first-line treatment of metastatic renal cell carcinoma over the last 5-10 years, summarized by Dr. Powles in his EUO lecture.