Bladder cancer continues to afflict more than 80,000 patients in the United States and at least 550,000 persons globally.1,2 Although the scientific community could not meet in person last year due to the COVID-19 pandemic, this did not stop the ongoing exchange of ideas, research, and clinical trials. In this article, I highlight some of the most important advances in non-muscle invasive bladder cancer (NMIBC) and the key data to anticipate in 2021.