(UroToday.com) SARS-CoV-2 entry into host lung cells is facilitated by the transmembrane protease TMPRSS2, which is expressed in both lung and prostate tissue. Pre-clinical data has suggested that TMPRSS2 expression can be modulated by the androgen receptor and that androgen deprivation therapy may protect patients from SARS-CoV-2 infection and decrease the severity of COVID-19.