(UroToday.com) While advanced bladder cancer has a generally poor prognosis, there are notable gender-based differences. While women have a lower incidence of bladder cancer, they are, in general, diagnosed with more advanced disease at presentation. Further, even when tumor stage and treatment approach are accounted for, women have worse outcomes. However, the basis of these discrepancies is, to date, unknown. To address this, in a poster presentation at the 2021 ASCO GU Cancers Symposium, Dr. Truong and colleagues sound to assess germline variants among women with bladder cancer which may explain their poor prognosis.