Avelumab initially received regulatory approval for patients with metastatic urothelial carcinoma in the post-platinum chemotherapy setting based on an objective response rate of 16.5%.1  In the post-platinum chemotherapy setting, both nivolumab and pembrolizumab also currently retain their regulatory approval status.  However, the situation where avelumab has the strongest data is in the maintenance-switch setting.  I initially discussed that topic in a Urotoday Clinical Trials Portal article almost 4 years ago.2  Of course, everything discussed in that article has been completed, and all highlighted trials were positive.

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