(UroToday.com) Treatment options for men with metastatic castration resistant prostate cancer (mCRPC) are limited beyond taxane chemotherapy and second-generation androgen pathway inhibitors. Moreover, resistance to these agents is associated with the emergence of small cell neuroendocrine prostate cancer in a subset of patients (tSCNC), portending poor prognosis. Additional therapeutic options are required for patients who have progressed on the multiple therapies approved in mCRPC, especially for patients with tSCNC.

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