Neoadjuvant cisplatin-based chemotherapy in patients with muscle-invasive bladder cancer (MIBC) before radical cystectomy improves overall survival. Commonly used neoadjuvant chemotherapy regimens include the combination of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) or a combination of gemcitabine and cisplatin (GC).

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