(UroToday.com) The Société Internationale D’Urologie (SIU) 2021 annual meeting included a plenary session with the AUA lecture provided by Dr. Sam Chang discussing the 2021 AUA Guideline for renal masses and localized cancer, specifically evaluation, management, and follow-up.1,2 Dr. Chang notes that the AUA guidelines focus on the evaluation and management of clinically localized sporadic renal masses suspicious for renal cell carcinoma (RCC) in adults. This includes solid-enhancing renal tumors and Bosniak 3 and 4 complex cystic renal lesions. Dr. Chang also notes that this guideline addresses the follow-up of renal cancer patients after intervention, including periodic clinical follow-up, abdominal imaging, and chest imaging. The methodology for this guideline is comparable to previous AUA guidelines, as summarized in the following table: