(UroToday.com) At the Oligometastatic Disease in Genitourinary Cancers session at the 2020 virtual meeting of the European Multidisciplinary Congress on Urological Cancers, Dr. Henk van der Poel discussed important definitions and disease biology. The argument of contiguous versus systemic disease spread dates back to Halsted who suggested that breast cancer is a disease that spreads in an orderly and typically contiguous manner: from the breast to the lymph nodes and then to other distant metastatic sites. However, Fisher suggested that breast cancer is considered a systemic disease at the time of diagnosis. From a urologic perspective, cases of metastasectomy for kidney cancer date back to 1939; a recent systematic review of surgical metastasectomy for patients with renal cell carcinoma suggests that complete resection of disease is associated with 7% long-term survival.1