EAU 2020: Results from the phase III study of Nadofaregene Firadenovec: Safety and Efficacy in Patients with High-grade, BCG-unresponsive Non-Muscle Invasive Bladder Cancer

(UroToday.com) As part of the “Game-changing Session 2” plenary presentation at the European Association of Urology (EAU) Virtual Annual Meeting, Dr. Neal Shore presented results of the phase III trial of nadofaregene firadenovec in patients with high-grade, bacillus calmette-guerin or BCG-unresponsive non-muscle invasive bladder cancer on behalf of Dr. Boorjian, Dr. Dinney, and the Society of Urologic […]

EAU 2020: Limitations of PSMA Based on Prostate Cancer Biology

(UroToday.com) Prostate membrane antigen (PSMA) is a type 2 transmembrane protein with an enzymatic function of a folate hydrolase carboxypeptidase. It is expressed in several tissues with different functions, including activity in Glial cells, modulating signal transduction pathway, in the small intestine, assisting in fulling absorption, and it has an uncertain role in the prostate (figure […]

EAU 2020: Definition of Very High-Risk and Refractory Non-Muscle Invasive Bladder Cancer

(UroToday.com) According to the EAU guidelines, the treatment recommendations for high risk non-muscle invasive bladder cancer (NMIBC) include full dose BCG instillations for 1-3 years or radical cystectomy. BCG reduces the risk of progression in NMIBC, but 30% of T1G3 will require deferred radical cystectomy. In T1G3, five-year disease-related death after BCG occurs in 11.3% of […]

EAU 2020: Critical Assessment of Radioligand Therapy

(UroToday.com) There has been significant progress in the last century in the treatment of advanced prostate cancer (Figure 1). Figure 1- Treatment changes in Prostate cancer: The older generation radioisotope treatments such as strontium, samarium, and radium were directed to areas of increased bone turnover in bone metastasis, and they were not prostate cancer-specific. They are […]

A comparative study of autologous rectus fascia pubovaginal sling surgery and synthetic transobturator vaginal tape procedure in treatment of women with urodynamic stress urinary incontinence.

To compare short term results of autologous rectus fascia pubovaginal sling surgery with synthetic transobturator vaginal tape procedure in treatment of female stress urinary incontinence (SUI) STUDY DESIGN: It was a comparative study on 30 women between 25-65 years of age with urodynamic proven SUI who were randomly allocated to autologous rectus fascia pubovaginal sling […]

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