(UroToday.com) Dr. Kenneth Pienta gave a short overview of prostate-specific membrane antigen (PSMA) radioligand therapy. PSMA is a transmembrane carboxypeptidase highly expressed on prostate cancer cells. Its expression has been observed in more than 95% of prostate cancer tumors. There is a direct correlation between PSMA expression levels and tumor aggressiveness.
(UroToday.com) In this session, Dr. Christopher Evans began the session presenting an index case of a man with a PSA of 5.2, who later underwent a prostate biopsy demonstrating Gleason grade Group 1 cancer only. Later, the patient had an Oncotype test done, showing a GPS score of 21. The patient went on to undergo a […]
(UroToday.com) Positive surgical margins represent a poor prognostic factor at the time of radical prostatectomy.1 However, there have been conflicting results as to the prognostic implications of positive surgical margins in the literature.2 The objective of the current study was to investigate the impact of positive surgical margins, its length, the focality, and the Gleason […]
(UroToday.com) Prostate cancer after primary non-surgical treatment of prostate cancer is common. The vast majority of recurring patients (~90%) undergo androgen deprivation therapy, regardless of the recurrence site. However, certain men with biochemical recurrence after primary treatment can be managed with curative intent by salvage radical prostatectomy. Historical series show high complication rates and poor outcomes, […]
(UroToday.com) Active surveillance aims to reduce overtreatment in patients with low-risk prostate cancer and has, as initial treatment, excellent prostate cancer-specific survival.1-2 The reduction of overtreatment is, however, limited due to a high rate of discontinuation.3 Magnetic resonance imaging (MRI) enables a more accurate sampling of prostate cancer, and the use of MRI before inclusion […]
(UroToday.com) Ga-RM2 (Bombesin Analog) Gastrin releasing peptide receptor antagonist is a G protein-coupled receptor, which is overexpressed in a variety of major human cancers such as prostate, breast, small lung cancer and the tumoral vessels of urinary tract cancers.
(UroToday.com) Anthony Fauci, MD, gave a presentation on the current worldwide pandemic caused by COVID-19. He began his talk showing the Coronavirus phylogenetic tree (Figure 1). Figure 1- Coronavirus phylogenetic tree with human Coronaviruses shown in red: Before the COVID-19 pandemic, two other coronaviruses have caused limited outbreaks in the recent past. These include the: […]
(UroToday.com) After the recurrence of non-muscle invasive bladder cancer following Bacillus Calmette-Guerin (BCG) therapy, risk-stratified management directs patients toward radical cystectomy, clinical trial enrollment, and off-label use of intravesical chemotherapy. Many patients remain unfit for or unwilling to have major extirpative surgery. Pragmatically, 20% of patients with high-grade disease should have a cystectomy: from 2004-2013, only […]
(UroToday.com) The aim of prostate cancer screening is to diagnose the patient early, which increases their chance of cure and subsequently reduces suffering and dying from the disease. In the European Randomized study of Screening for Prostate Cancer (ERSPC) this concept was tested and confirmed, with many high-impact publications over the past two decades.1-3 At […]
(UroToday.com) The novel micro-ultrasound system operating at 29 MHz operates at a higher level than the conventional 6-9 MHz systems. This results in 300% improvement in resolution, both axial and laterally down to 70 microns, allowing visibility of suspicious areas using the prostate risk identification using a micro-ultrasound (PRI-MUS) system.1 Micro-ultrasound may be used to image […]
