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Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. We enrolled 389 patients who […]

Monotherapy with high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy are both recommended modalities for prostate cancer. The choice between HDR and LDR is dependent on patient, physician, and hospital preferences. We sought to identify treatment patterns and factors associated with receipt of HDR or LDR monotherapy. We queried the National Cancer Database (NCDB) for patients with […]

Bacillus Calmette‑Guérin (BCG) has become a significant treatment for bladder cancer, and neutrophils are reported to be associated with the antitumor effect of BCG. The aim of the present study was to clarify the antitumor function of neutrophils stimulated by BCG. Initially, the killing effect and cytotoxic activity of neutrophils treated with BCG was detected. […]

The Bladder Cancer Index (BCI) and Functional Assessment of Cancer Therapy-Bladder-Cystectomy (FACT-Bl-Cys) were developed to measure disease-specific health-related quality of life (HRQOL) in bladder cancer patients and patients treated with radical cystectomy, respectively. Both patient-reported outcome measures (PROMs) are frequently used in clinical practice, but are not yet validated according to the COSMIN criteria and […]

Telomerase reverse transcriptase (TERT) promotor mutations occur in majority of cancers and are of notably meaning for tumor research. In bladder cancer the TERT promotor mutations exist in all stages and grades and are more frequent than other earlier reported genetic alterations. Here we report TERT promotor mutation status in primary bladder cancer samples related […]

Gerhardt Attard: Silke, Aurelius, thank you for asking me to speak about this topic. So a question I’ve been interested in since I realized that in the mHSPC trials, we were using a dose of prednisone 5mg daily in combination with abiraterone. Those are my disclosures, all very relevant to this talk. So the aim […]

Anwar Padhani: Good afternoon, everybody. I too would like to thank Silke and Aurelius for inviting me along today. Here are my disclosures, and as you might imagine, it’s imaging companies. We’ve all heard consistently I think over the last two days that bone scans and CT scans lead to poor confidence in knowing what […]

Howard Scher: It’s a pleasure to be here, and thank you for the invitation. I’m going to try and approach this topic both from a point of view of a clinician as well as a researcher. So here are my disclosures. The first thing, that first question I asked is, “What is this entity?” And […]

Michael Hofman: Thank you. It’s a pleasure to be here and present our evolving experience with PSMA theranostics. My disclosure and thank you is to Endocyte, now AAA Novartis, for supporting this research. We’ve heard a lot about PSMA. I have to pinch myself every now and again and make sure we’re not at a […]