Cancer is a major cause of death worldwide. MET tyrosine kinase receptor [MET, c-MET, hepatocyte growth factor (HGF) receptor] pathway activation is associated with the appearance of several hallmarks of cancer. The HGF/MET pathway has emerged as an important actionable target across many solid tumors; therefore, biomarker discovery becomes essential in order to guide clinical […]
Proton and carbon ion radiotherapy for the treatment of prostate cancer is associated with a lower incidence of adverse events than conventional radiotherapy. There are few reports on the quality of life of patients treated with particle therapy, and limited patient-reported outcomes. Analysis of quality of life is important for patients treated with radiotherapy alone […]
Almost three decades ago the first laparoscopic nephrectomy was performed. It was a controversial approach at the time, but over time the technique improved and we even started doing laparoscopic partial nephrectomies. However, partial nephrectomy is a technically challenging procedure and laparoscopy was a convenient option for simpler tumors. More complex tumors still required open […]
In daily medical practice, patients who are alone or without a spouse appear less inclined to accept therapies or follow medical recommendations. Previously studies demonstrated that unmarried status is a known risk factor for poor cancer control outcomes and survival in several malignancies.1-4 Since no contemporary data exists to specifically address the role of marital status […]
The discovery and validation of novel molecular targets useful in various cancers is of great importance, even more so when they can be used for both diagnosis and therapy (theragnostic). 68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptors (GRPR). GRPR proteins are highly overexpressed in several human tumors, including […]
Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Metastatic Prostatic Adenocarcinoma Condition: Prostate Cancer Intervention: Drug: Apalutamide Drug: Abiraterone Acetate Drug: Prednisone Procedure: Radical Prostatectomy Procedure: Extended Pelvic lymphadenectomy Drug: GnRH agonist/antagonist Purpose: The purpose of this study is to test if treatment with medications that reduce the male hormone level in […]
Increased computational power and improved visualization hardware have generated more opportunities for virtual reality (VR) applications in healthcare. In this study, we test the feasibility of a VR-assisted surgical navigation system for robotic-assisted radical prostatectomy. The prostate, all magnetic resonance imaging (MRI) visible tumors, and important anatomic structures like the neurovascular bundles, seminal vesicles, bladder, […]
Nerve-sparing robot-assisted radical prostatectomy has decreased the post-surgical complications of prostate surgery, but has not eliminated it. The ability to view the microstructure will enable better surgical decisions and lead to better post-surgical outcomes. An ideal imaging modality should provide rapid image acquisition, be low cost, and be specific to the tissue being examined. This […]
We describe the longitudinal adoption of conservative management (ie, the absence of treatment) for prostate cancer among urology group practices in the United States and identify group practice features that influence this adoption. Using a 20% sample of Medicare claims, we identified men with incident prostate cancer from 2010 through 2014 and assigned each to […]
Transrectal, ultrasonography-guided prostate biopsy often fails to disclose the severity of underlying pathologic findings for prostate cancer. Magnetic resonance imaging (MRI)-guided biopsy may improve the characterization of prostate pathologic results, but few studies have examined its use for the decision to enter active surveillance. To evaluate whether confirmatory biopsy findings by MRI guidance are associated […]
