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Prospective validation of gallium-68 (68Ga) prostate specific membrane antigen (PSMA)-PET/CT in initial staging of prostate cancer is lacking. This study evaluates diagnostic accuracy of 68Ga-PSMA-PET/CT in detection of lymph node metastases in patients with intermediate-high risk prostate cancer. From October 2017 to October 2018, newly diagnosed prostate cancer patients with negative bone scan and >10% […]

Prostate specific antigen (PSA) screening for prostate cancer has recently been challenged due to poor sensitivity. A number of conditions elevate PSA besides prostate cancer with benign prostatic hypertrophy (BPH) being most common. The objective of this study was to assess the positive predictive value (PPV) of PSA and PSA density (PSAD) for prostate cancer […]

Kidney cancer is the predominant form of malignancy of the kidney and accounts for approximately 3%-4% of all cancers. Renal cell cancer (RCC) represents more than 85% of kidney cancer. It has been reported that genetic factors may predispose individuals to RCC. This study evaluated the association between Acylphosphatase 2 (ACYP2) gene polymorphisms and RCC […]

Previous communication has reported significant improvement in overall survival (OS) when using doxorubicin plus sorafenib in the treatment of advanced hepatocellular cancer (HCC). To determine if doxorubicin added to sorafenib therapy improves OS, with stratification for locally advanced and metastatic disease. This unblinded randomized phase 3 clinical trial was led by Alliance in collaboration with […]

Renal carcinoma is the second most common cancer in the urinary system with an increasing trend. The major treatment for renal carcinoma is surgery, which results in unfavorable prognosis at times. As a tissue-specific marker for tumor, microRNA (miR) exerts its functions via facilitating oncogenic gene expression or suppressing tumor suppressor gene. MiR-184 is known […]

Erectile dysfunction is a sexual dysfunction which is commonlycomorbid with major depression. Antidepressant treatment does notalways improve comorbid sexual dysfunctions in major depression. Infact, sexual dysfunction may worsen or get complicated following theintroduction of antidepressants. Modafinil is a drug with stimulanteffect on the central nervous system by binding to norepinephrineand dopamine transporters and consequently increasing […]

To assess renal function, graft survival rates and the risk of graft loss in children based on the etiology with focus on differences between urologic causes from congenital anomalies of the kidney and urinary tract (CAKUT) versus other causes of end-stage kidney disease (ESKD). A retrospective chart review was performed that included patients <18 years […]

San Francisco, CA (UroToday.com) — Dendreon Pharmaceuticals, a commercial-stage biopharmaceutical company and pioneer in the development of immunotherapy, announced the publication of results from its PROCEED registry, which evaluated real-world use of PROVENGE®(sipuleucel-T) in men with asymptomatic or minimally symptomatic metastatic castrate-resistant prostate cancer (mCRPC). The findings, published in Cancer1 showed that men with mCRPC who were […]

Background: The large registry, PROVENGE Registry for the Observation, Collection, and Evaluation of Experience Data (PROCEED) (NCT01306890), evaluated sipuleucel‐T immunotherapy for asymptomatic/minimally symptomatic metastatic castration‐resistant prostate cancer (mCRPC). Methods: PROCEED enrolled patients with mCRPC receiving 3 biweekly sipuleucel‐T infusions. Assessments included overall survival (OS), serious adverse events (SAEs), cerebrovascular events (CVEs), and anticancer interventions (ACIs). Follow‐up was […]

To analyze the number of mpMRI targeted biopsy (TBx) cores per lesion needed for PCa detection in patients treated with radical prostatectomy (RP). Analyses focus on TBx of PCa suspicious MRI lesions (PI-RADS ≥3) with consecutive RP. Descriptive statistics included frequencies/proportions and interquartile ranges (IQR). Multivariable logistic regression analyses (MVA) on per lesion level predicted […]