Increasing evidences have proved that long noncoding RNAs (lncRNAs) regulate the occurrence of bladder cancer (BC) and participate in various pathophysiology processes. However, little is unknown about the role of lncRNAs in drug resistance of BC cells.
The present systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs) aimed to compare the mortality rates related to adverse events (AEs) and discontinuation of treatment due to toxicity as well as all AEs of currently used chemotherapy regimens for first-line therapy of advanced or metastatic urothelial carcinoma of the bladder (UCB).
RAF kinases are critical proteins in the MAPK cascade, essential for cancer cell processes such as proliferation and migration. RAF1 functions as an obligate homodimer or heterodimer with BRAF. The role of RAF1 amplifications as drivers or therapeutic targets in bladder cancer is unclear.
Purpose: Patients discontinuing immuno-oncology regimens may experience periods of disease control without need for ongoing anticancer therapy, but toxicity may persist. We describe treatment-free survival (TFS), with and without toxicity.
Zachary Klaassen: Hello and thank you for joining us for this UroToday discussion of the NCCN Clinical Practice Guidelines in Oncology, specifically looking at prostate cancer version 1.2022. And today we will be discussing active surveillance. The active surveillance portion of the NCCN guidelines is quite robust as you can see here. There are six […]
EAU21 was not only a scientific highlight for urology in its own right, but it played an important part for the future of the Association too. At the General Assembly on 12 July 2021, which was the first in over two years, existing EAU Board members could formally retire and be succeeded by their replacements. […]
Therapeutic options for metastatic prostate cancer patients are currently limited. In this issue of Cancer Cell, Kfoury et al. characterized the tumor and immune compartments of prostate cancer bone metastasis, revealing a mechanism of immunosuppression that involves infiltration with M2 macrophages and T cell exhaustion mediated by the CCL20-CCR6 axis.
Enzalutamide resistance has been observed in approximately 50% of patients with prostate cancer (PCa) bone metastases. Therefore, there is an urgent need to investigate the mechanisms and develop strategies to overcome resistance.
Prostate cancer (PCa) is a pervasive condition that is manifested in a wide range of histologic patterns in biopsy samples. Given the importance of identifying abnormal prostate tissue to improve prognosis, many computerized methodologies aimed at assisting pathologists in diagnosis have been developed.
Several conditions can cause penile length and girth loss. Surgical techniques have been used to restore these penile alterations in patients with severe erectile dysfunction during penile prosthesis implantation.
