ESMO 2021: IMvigor011: A Global, Double-Blind, Randomized Phase 3 Study of Atezolizumab Versus Placebo As Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Post Cystectomy

(UroToday.com) The European Society of Medical Oncology (ESMO) 2021 annual meeting’s non-prostate cancer session included a presentation by Dr. Thomas Powles discussing the IMvigor011 trial concept and design, a phase 3 trial assessing atezolizumab versus placebo as adjuvant therapy in patients with high-risk muscle-invasive bladder cancer (MIBC) who are ctDNA positive after a radical cystectomy.

ESMO 2021: Treatment Patterns and Overall Survival in Metastatic Castration-Sensitive Prostate Cancer from 2006 to 2019

(UroToday.com) The European Society of Medical Oncology (ESMO) 2021 annual meeting’s prostate cancer session included a presentation by Dr. Stephen Freedland discussing treatment patterns and overall survival among men with metastatic castration-sensitive prostate cancer (mCSPC). Indeed, androgen deprivation therapy (ADT) remains the backbone of therapy for mCSPC. While earlier studies (pre-2012) adding first-generation nonsteroidal antiandrogens to […]

ESMO 2021: The Phase 2 NORSE Trial Discussion: A Novel Combination in the First-Line Setting for Patients With Metastatic or Locally Advanced Urothelial Carcinoma and FGFR Alterations

(UroToday.com) In this presentation, Dr. Srikala Sridhar discussed results from the Phase 2 NORSE study of erdafitinib or erdafitinib plus cetrelimab in patients with metastatic or locally advanced urothelial carcinoma (UC) and fibroblast growth factor receptor (FGFR) alterations. This study addresses a significant unmet clinical need for better first-line therapy options for patients with metastatic UC […]

ESMO 2021: Apalutamide Efficacy and Safety in Asian Patients with Metastatic Castration-Sensitive Prostate Cancer

(UroToday.com) The European Society of Medical Oncology (ESMO) 2021 annual meeting’s prostate cancer session included a presentation by Dr. Byung Ha Chung discussing the efficacy and safety of apalutamide use in Asian patients with metastatic castration-sensitive prostate cancer (mCSPC). In TITAN study, the addition of apalutamide to androgen deprivation therapy (ADT) significantly improved radiographic progression-free survival […]

ESMO 2021: Erdafitinib (ERDA) or ERDA Plus Cetrelimab (CET) for Patients With Metastatic or Locally Advanced Urothelial Carcinoma (mUC) and Fibroblast Growth Factor Receptor Alterations (FGFRa): First Phase 2 Results From the NORSE Study

(UroToday.com) In this presentation, Dr. Thomas Powles presented results from the Phase 2 NORSE study of erdafitinib or erdafitinib plus cetrelimab in patients with metastatic or locally advanced urothelial carcinoma (UC) and fibroblast growth factor receptor (FGFR) alterations. These preliminary results discussed by Dr. Thomas Powles focused on overall response rate (ORR) and safety data.

ESMO 2021: CABOPRE: A Phase II Study of Cabozantinib (Cabo) Prior Cytoreductive Nephrectomy (CN) in Metastatic Renal Cell Carcinoma (mRCC)

(UroToday.com) In the on-demand poster session of the European Society for Medical Oncology (ESMO) Annual Congress, Dr. Guillermo De Velasco discussed the CABOPRE trial, a single-arm prospective multicentre phase II trial to assess the efficacy and safety of neoadjuvant cabozantinib in patients with clear cell metastatic renal cell carcinoma (mRCC) and potential candidates to cytoreductive […]

ESMO 2021: Final Results on Efficacy and Patient Reported Outcomes (PRO) of a Randomized Phase II Trial Investigating Nivolumab Switch-Maintenance After TKI Induction in Metastatic Clear Cell Renal Cell Carcinoma (mRCC) Patients (NIVOSWITCH)

(UroToday.com) In the on-demand poster session of the European Society for Medical Oncology (ESMO) Annual Congress, Dr. Christopher Darr presented results of the phase II NIVOSWITCH trial assessing whether a 1st line switch-maintenance approach (CPI after TKI) improved outcome in metastatic clear cell renal cell carcinoma (mRCC). Each of these treatment approaches (CP and TKI) […]

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