Reports on over-expression of the epidermal growth factor receptor (EGFR) in bladder cancer and its function in tumorigenesis have suggested to target this antigen. We generated the targeted toxin EGF-PE40 consisting of the human epidermal growth factor (EGF) as the binding domain and PE40, a truncated version of Pseudomonas Exotoxin A, as the toxin domain.
Deleterious mutations in PBRM1 are frequent in cancer, especially in clear cell renal cell carcinoma where they are an early driver event occurring subsequent to VHL alteration in approximately 40% of patients – representing ≈ 175,000 new cases worldwide every year. Until recently, PBRM1 defects were often overlooked in clinical practice because there was no […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Timothy A. Masterson from Indiana University discussed local management of the penile primary tumor. Dr. Masterson started by highlighting that local recurrences occur secondary to surgical technique, pathological stage, and surgical margin status. This also […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Philippe Spiess from the Moffitt Cancer Center discussed the management of locally recurrent penile cancer. Dr. Spiess started by highlighting a case presentation of a 56-year-old male presenting with a fungating penile tumor and bulky […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Viraj Master from Emory University discussed the management of inguinal lymph nodes in patients with no palpable adenopathy and in patients with non-bulky lymph nodes (<3-4 cm). According to Dr. Master, it is very difficult […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Christopher Protzel from the University of Rostock discussed the management of bulky inguinal and pelvic lymph nodes. Dr. Protzel started with a case presentation of a 49-year-old male, former smoker, with no medical comorbidities who […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Philippe Spiess from the Moffitt Cancer Center started the course with an introduction and highlighting the global impact of penile cancer in 2021. Dr. Spiess notes that in 2021, there will be an estimated 2,210 new […]
(UroToday.com) At the 2021 American Urological Association (AUA) Summer School session on the updates in the management of penile cancer, Dr. Andrea Necchi from IRCCS San Raffaele Hospital and Scientific Institute in Milan discussed the perioperative treatment of penile cancer. Dr. Necchi notes that the prognosis of penile cancer is predictable based on the importance of […]
Real-world data suggest Decipher test’s risk scores are independently associated with conversion to definitive treatment and with treatment failure San Francisco, CA (UroToday.com) — Veracyte, Inc. announced new data suggesting the Decipher® Prostate Biopsy genomic classifier (GC) may help guide treatment decisions for prostate cancer patients who are candidates for active surveillance (AS). The findings, from a […]
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study.
