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Androgen deprivation, which can be accomplished via drug treatment using gonadotropin-releasing hormone (GnRH) agonists, antiandrogens, or both combined, is widely used in the treatment of prostate cancer. Androgen deprivation therapy (ADT) can delay cancer progression and be life-prolonging. As with almost all cancer treatments, ADT comes with side effects and one of the most concerning […]

Metastasis has classically been considered a binary state, which has heavily influenced treatment paradigms to favor systemic therapy. Recently, mounting evidence suggests metastasis is a spectrum of disease rather than a simple binary entity resulting in the notion of a potentially curable low-volume metastatic state with metastasis-directed local therapy. Significant efforts have been underway to […]

Background: Targeted sequencing of circulating tumour DNA (ctDNA) is a promising tool to monitor dynamic changes in the variant allele frequencies (VAF) of genomic alterations and predict clinical outcomes in patients with advanced urothelial carcinoma (UC).

To date, there are no preoperative and quantitative dynamics in clinical practice that can reliably differentiate between a benign and malignant renal cell carcinoma (RCC). For monitoring different analytes in body fluids, more than 40 different molecular biomarkers have been identified, however, they are associated with limited clinical sensitivity and/or non-optimal specificity due to their […]

This study aims to identify potential prognostic and therapeutic biomarkers in papillary renal cell carcinoma (pRCC). Two microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified.

Stereotactic body radiotherapy (SBRT) has potential radiobiologic and economic advantages over conventional fractionated radiotherapy (CFRT) in localized prostate cancer (PC). This study aimed to compare the effects of these two distinct fractionations on patient-reported quality of life (PRQOL) and tolerability.

African-American (AA) men are more than twice as likely to die of prostate cancer (PCa) than European American (EA) men. Previous in silico analysis revealed enrichment of altered lipid metabolic pathways in pan-cancer AA tumors.

Cloquet’s node, located at the junction between the deep inguinal nodes and the external iliac chain, is easily accessible and commonly excised during pelvic lymph node dissection for prostate cancer.

The role of endogenous testosterone in de novo prostate cancer pathogenesis in humans remains unclear. The effect of testosterone on the tumor genome is not explored. To explore the correlation between perioperative testosterone level on genomic risk score in a cohort of men who underwent radical prostatectomy.

Aim: To assess homologous recombination repair mutation (HRRm) testing patterns in metastatic castration-resistant prostate cancer. Methods: A point-in-time, international survey conducted January-August 2020.