FDA Grants Regular Approval and Expands Indication for PADCEV® for Patients with Locally Advanced or Metastatic Urothelial Cancer

– Regular Approval Based on Overall Survival Results from Confirmatory EV-301 Trial – – First and Only FDA-Approved Therapy for Urothelial Cancer Patients Who Are Cisplatin-Ineligible and Have Previously Received One or More Prior Therapies, Based on Cohort 2 of Pivotal EV-201 Trial – San Francisco, CA (UroToday.com) — Seagen Inc. and Astellas Pharma Inc. announced […]

EAU 2021: How to Quantify Biopsy Gleason Grade 4 for Active Surveillance

(UroToday.com) Dr. Geert Van Leenders of the Netherlands provides the Pathology perspective on quantifying Gleason pattern 4 for active surveillance (AS). First, he highlights the fact that Gleason pattern for disease is a heterogeneous subset. Historically Gleason pattern 4 was a single entity – but recent research has demonstrated that Gleason pattern has multiple histologic subsets. […]

EAU 2021: Risk-Adapted Screening with Genomics and MRI: STHLM3 MR Phase 2 Trial

(UroToday.com) Dr. Tobias Nordstrom presented on the Stockholm3 MRI trial, which is a risk-adapted screening protocol incorporating genomics and MRI. The aim of this study was to compare traditional screening with web-based risk prediction combined with MRI-targeted biopsies for prostate cancer screening. This was a population-based screening-by-invitation noninferiority trial. The trial flow diagram is listed […]

Magnetic Resonance Imaging (MRI) Can Cut Overdiagnoses in Prostate-Cancer Screening by Half

San Francisco, CA (UroToday.com) — Most countries have not introduced nationwide prostate cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in The New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted biopsies could […]

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