Hematuria following post-prostatectomy radiotherapy (PPRT) is inadequately characterized. We performed a consecutive cohort study of patients treated with PPRT at our institution to characterize this complication including impact on patient-reported quality of life (PRQOL).
It has been suggested that androgen receptor copy number gain (AR gain) detected in cell-free DNA (cfDNA) can predict treatment response to androgen receptor signaling inhibitors (ARSIs) in patients with castration-resistant prostate cancer (CRPC).
Radiotherapy combined with androgen deprivation therapy (ADT) is a standard of care for high-risk prostate cancer. However, the interplay between radiotherapy dose and the required minimum duration of ADT is uncertain.
The STAMPEDE trial recruits men with newly diagnosed, high-risk, hormone-sensitive prostate cancer. To ascertain the feasibility of targeted next-generation sequencing (tNGS) and the prevalence of baseline genomic aberrations, we sequenced tumor and germline DNA from patients with metastatic prostate cancer (mPCa) starting long-term androgen-deprivation therapy (ADT).
Pretreatment estimates of seminal vesicle invasion (SVI) are challenging and significantly influence the management of prostate cancer. We sought to improve current models to predict SVI through the development of an SVI prediction genomic signature.
To analyse incidence, treatment strategies and complications of Penile Intraepithelial Neoplasia (PeIN) in Sweden over a period of 20 years. Data on PeIN from the Swedish National Penile Cancer Register was analysed regarding treatment in relation to age, size of the PeIN lesion, localisation of the PeIN lesion and complications using Chi-square tests and logistic […]
Aims: Immune checkpoint inhibitors (ICIs) have recently revolutionized the treatment landscape of metastatic urothelial carcinoma. The authors performed a meta-analysis aiming to evaluate the predictive value of Eastern Cooperative Oncology Group performance status, age, sex, liver metastasis and histology in trials comparing first-line ICI-based combinations with chemotherapy in metastatic urothelial carcinoma patients.
To determine the geographic distribution of muscle-invasive bladder cancer mortality according to race in the United States (US). African Americans (AAs) have up to two times the risk of bladder cancer mortality compared to Caucasians.
(UroToday.com) The 2022 EAU Section of Oncological Urology (ESOU) Annual Meeting included a session on locally advanced and metastatic renal cancer and a presentation by Dr. Shankar Siva discussing the role of stereotactic ablative body radiotherapy (SABR) for kidney cancer. Dr. Siva notes that renal cell carcinoma (RCC) has historically been considered a radioresistant disease. Looking […]
(UroToday.com) The 2022 EAU Section of Oncological Urology (ESOU) Annual Meeting included a session on locally advanced and metastatic renal cancer and a presentation by Dr. Lewis Au discussing liquid biomarkers in advanced kidney cancer. Dr. Au notes that the purpose of liquid biomarkers is to capture tumor genomic features through blood sampling. With regards to […]
