TRANSCRIPT: Journal Club – ENZAMET OS

Christopher Wallis: Hello, and thank you for joining us for this UroToday Journal Club. Today, we are discussing a recent publication entitled, Overall Survival of Men with Metachronous Metastatic Hormone-sensitive Prostate Cancer Treated with Enzalutamide and Androgen Deprivation Therapy. I’m Chris Wallis, a Fellow in Urologic Oncology at Vanderbilt. With me today is Zach Klaassen, […]

Three-Dimensional Deep Noninvasive Radiomics for the Prediction of Disease Control in Patients With Metastatic Urothelial Carcinoma Treated With Immunotherapy

Artificial Intelligence algorithms may automatically quantify radiologic characteristics associated with disease response to medical treatments. We investigated a 3-dimensional deep radiomics pipeline to predict disease control to immunotherapy in 42 consecutive patients with metastatic urothelial cancer. The predictive accuracy of the pipeline was 82.5% and increased to 92.5% with the addition of the imaging of […]

SNMMI 2021: A Phase 3 Study of 18F-DCFPyL-PET/CT in Patients With Biochemically Recurrence Prostate Cancer (CONDOR): An Analysis of Disease Detection Rate and Positive Predictive Value by Anatomic Region

(UroToday.com) PSMA-targeted PET/CT is superior to conventional imaging modalities to localize biochemically recurrent prostate cancer after local therapy, particularly in patients with low PSA (< 2 ng/mL) values. However, few studies have reported PSMA-targeted PET/CT accuracy compared to a pre-specified rigorous standard of truth including histopathology, correlative imaging, or treatment response in this population. The […]

Attenuation of SRC Kinase Activity Augments PARP Inhibitor-Mediated Synthetic Lethality in BRCA2-Altered Prostate Tumors – Beyond the Abstract

Deleterious alterations in genes that are directly or indirectly associated with DNA damage repair (DDR) are enriched in lethal aggressive prostate cancer (PC). About 25–30% of patients with metastatic castration-resistant prostate cancer (mCRPC) harbor loss-of-function alterations in DDR genes and respond to current androgen receptor (AR) inhibitors.1 Recently, PARP inhibitors (PARPi) have shown promise in […]

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