ASCO 2021: Late Relapses and Toxicities in Testicular Cancer: Good and Bad News?

(UroToday.com) In this talk, Dr. Siamak Daneshman reviewed the prior two abstracts (5006 and 5007) which looked at non-testicular cancer-related deaths in testicular cancer survivors, and clinical features of late relapse disease broken down by chemotherapy exposure and histology, respectively. He first provided his own timeline of major landmarks in germ cell tumor management.

ASCO 2021: SWOG S1216: A Phase III Randomized Trial Comparing Androgen Deprivation Therapy (ADT) plus TAK-700 with ADT plus Bicalutamide in Patients with Newly Diagnosed Metastatic Hormone-Sensitive Prostate Cancer

(UroToday.com) Metastatic prostate cancer continues to be driven by androgen signaling, in part through androgen synthesis via CYP17A1 lyase activity. Abiraterone acetate is an FDA-approved inhibitor of CYP17 hydroxylase and lyase activity that has shown clinical benefit when added to chemical castration in advanced prostate cancer but results in mineralocorticoid excess due to inhibition of hydroxylase […]

ASCO 2021: Causes of Death and Mortality Rates in a Population-Based Cohort – Testicular Cancer in the Cisplatin Era

(UroToday.com) Testicular cancer is the most common cancer in young men, with a very high cure rate largely attributable to the development of cisplatin-based chemotherapy. However, testicular cancer survivors experience excess mortality compared to the general population. To highlight this, she showed the figure below. When focusing on patients diagnosed after 1980, there is a drop-off […]

ASCO 2021: Pembrolizumab in Combination With Gemcitabine and Concurrent Hypofractionated Radiation Therapy As Bladder Sparing Treatment for Muscle-Invasive Urothelial Cancer of the Bladder: A Multicenter Phase 2 Trial

(UroToday.com) Curative intent therapy in muscle invasive bladder cancer (MIBC) can be accomplished by either cisplatin-based chemotherapy followed by radical cystectomy, or trimodality bladder preservation therapy via maximal transurethral resection of the bladder tumor (TURBT) followed by chemoradiation. No randomized trials have compared these two options, though propensity risk-matched cohort analyses suggest similar outcomes. Furthermore, the […]

Safety and Efficacy Study of Collagenase Clostridium Histolyticum Applied With an Intensive Protocol in the Treatment of Peyronie’s Disease.

Collagenase clostridium histolyticum (CCH) is a treatment for Peyronie’s disease (PD) whose efficacy and safety has been demonstrated using a classic protocol and a shortened protocol. To evaluate the efficacy and safety of an even more intense protocol in which a CCH injection is applied for 3 separate cycles of 1 week.

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