Radiomics is a field of science that aims to develop improved methods of medical image analysis by extracting a large number of quantitative features. New data have emerged on the successful application of radiomics and machine-learning techniques to the prediction of muscle-invasive bladder cancer (MIBC).
Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach for targeting and killing tumor cells, and evidence of its clinical potential (ClinicalTrials.
(UroToday.com) In this summary of the preceding three presentations, Dr. Lisa Horvath showed where each abstract falls within the natural history of prostate cancer.
(UroToday.com) Current prostate-specific antigen (PSA) screening guidelines suggest an individualized approach and shared decision-making model based on patient preference and certain risk factors such as family history or race. The clinical trials that largely have guided screening recommendations notably either did not report race or did not enroll a significant proportion of self-identified African American patients, […]
Alicia Morgans: Hi, my name is Alicia Morgans and I’m a GU Medical Oncologist and Associate Professor of Medicine at Northwestern University in Chicago in the U.S. I’m so excited to have here with me today Dr. Andrea Necchi, who is a Professor of Medicine and a GU Oncologist in Milan at San Raffaele. Thank […]
(UroToday.com) Bone strengthening agents such as bisphosphonates or the RANKL-targeting antibody denosumab reduced the bone loss associated with androgen deprivation therapy (ADT) and prevent skeletal-related events in castration resistant prostate cancer (CRPC). The use of these agents is recommended in CRPC by many guidelines.
(UroToday.com) Dr. Peter Black reviewed the prior three abstracts, focused on addressing the increased incidence and mortality in African American men (AAM) with prostate cancer. He framed his discussion around points brought up by a previous presenter, that prostate cancer outcomes could be equivalent by race if all patients received a timely diagnosis, had adequate staging […]
(UroToday.com) African American men (AAM) have a higher incidence and mortality from prostate cancer, but disease-specific outcomes may be identical if there is a timely diagnosis, appropriate staging, and equitable and adequate treatment delivered. Disease risk-stratification by the NCCN only includes certain clinical parameters and does not capture underlying tumor biology or genomic diversity. Dr. Kosj […]
(UroToday.com) The phase 3 PEACE-1 began accruing in 2013, after which the therapeutic landscape of mCSPC has changed drastically. Initially, androgen deprivation therapy (ADT) alone was standard of care for castration-sensitive metastatic prostate cancer. However, in 2015, docetaxel was shown to improve survival. In 2017 the LATITUDE and STAMPEDE showed the survival advantage of the addition […]
(UroToday.com) Neoadjuvant cisplatin-based chemotherapy is associated with pathologic complete response (pCR) in muscle-invasive bladder at the time of cystectomy for a proportion of patients with muscle-invasive bladder cancer (MIBC). Patients with a pCR have improved overall survival relative to patients with no pCR. A challenge in the treatment of patients with MIBC is identifying patients that […]
