ASCO 2021: Outcomes of Patients Who Progressed While Receiving Avelumab + Axitinib and Received Subsequent Treatment in JAVELIN Renal 101

(UroToday.com) Renal cell carcinoma is the most common kidney cancer and constitutes approximately 3% of all malignant tumors in adults. Renal cell carcinoma is often first detected at an advanced stage, with 25% to 30% of patients with metastatic disease at diagnosis. Avelumab is a human immunoglobulin G1 (IgG1) monoclonal antibody targeting PD-L1 that was […]

ASCO 2021: Association of C-Reactive Protein With Efficacy of Avelumab + Axitinib in Advanced Renal Cell Carcinoma: Long-Term Follow-Up Results From JAVELIN Renal 101

(UroToday.com)  There have been transformational changes in first-line therapy for patients with advanced renal cell carcinoma (RCC) in the past three years. Foremost among these is the move from monotherapy to combination approaches. While CheckMate 214 first brought combination therapy with dual checkpoint inhibition to the forefront, subsequent studies have examined combinations of immune checkpoint […]

ASCO 2021: Older, Wiser, and Better: Clinical Trial Enrollment and Optimal Care for Older Adults with Kidney and Bladder Cancer

(UroToday.com) At the American Society of Clinical Oncology (ASCO) 2021 Annual Meeting,  during the session entitled “Breaking Barriers: Ensuring Equity in Cancer Diagnosis, Treatment, and Trial Enrollment for Patients with Kidney and Bladder Cancers,” Dr. Ravindran Kanesvaran presented on how we may optimize care, including clinical trial enrollments for older patients with kidney and bladder […]

ASCO 2021: Integrating Peripheral Biomarker Analyses From JAVELIN Renal 101: Avelumab + Axitinib vs Sunitinib in Advanced Renal Cell Carcinoma

(UroToday.com) There have been transformational changes in first-line therapy for patients with advanced renal cell carcinoma (RCC) in the past three years. Foremost among these is the move from monotherapy to combination approaches. While CheckMate 214 first brought combination therapy with dual checkpoint inhibition to the forefront, subsequent studies have examined combinations of immune checkpoint inhibitors […]

ASCO 2021: Regulating Change: The FDA and Diversity in the Modern Era of Genitourinary Oncology Trials

(UroToday.com) At the 2021 American Society of Clinical Oncology (ASCO) 2021 Annual Meeting, during the session entitled “Breaking Barriers: Ensuring Equity in Cancer Diagnosis, Treatment, and Trial Enrollment for Patients with Kidney and Bladder Cancers,” Dr. Chana Weinstock presented the role of the FDA to create a regulatory environment to encourage diversity in the modern era of […]

ASCO 2021: Phase II Trial of Atezolizumab in BCG-Unresponsive Non-Muscle Invasive Bladder Cancer: SWOG S1605

(UroToday.com) BCG is effective in the management of high-risk non-muscle-invasive bladder cancer (NMIBC), but recurrences are frequent. Furthermore, second-line therapies for BCG-unresponsive high-risk NMIBC remain inadequate. Radical cystectomy is the standard of care for patients with BCG-unresponsive high-risk NMIBC, but many patients are unfit for surgery or elect bladder preservation. At the 2021 American Society of Clinical […]

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