To evaluate the outcomes of high-grade T1 non-muscle-invasive bladder cancer treatment (NMIBC) in elderly patients over 80 years of age. This is a retrospective single tertiary-centre study.
Charles Ryan: Welcome. I’m delighted to be joined today by my friend, Scott Petinga. Scott is a serial entrepreneur, a testicular cancer survivor, and for today’s purposes, a really outstanding patient advocate for men with testicular cancer, as we discuss during Testicular Cancer Awareness Month. Scott, thank you for everything you do for cancer patients […]
Upper urinary tract urothelial carcinoma (UTUC) arises from the renal pelvicalyceal system and ureters and accounts for 5–10% of all urothelial carcinomas. After definitive UTUC treatment by radical nephroureterectomy with bladder cuff excision (RNU), 25-45% of the patients develop intravesical recurrences (IVR). Management of these recurrences is primarily extrapolated from primary bladder cancer (PBC) treatment […]
Positron emission tomography (PET) using a variety of tracers can reliably detect sites of prostate cancer before abnormalities can be appreciated using conventional imaging, particularly with respect to local recurrence and metastatic disease and 68Ga labelled PSMA ([68Ga]Ga-PSMA-11) tracer is the most widely reported.1 Our prospective study adds to the existing literature assessing the role […]
Patients with prostate cancer (PCa) have a high incidence of relapse and metastasis. Unfortunately, the molecular mechanisms underlying these processes have not been fully elucidated. In our study, we demonstrate that MUC15, a member of the mucin family, is a novel tumor suppressor in PCa that modulates epithelial-mesenchymal transition (EMT) and cancer stemness, contributing to […]
To evaluate the prognostic significance of circulating tumour cell (CTC) number determined on the Epic Sciences platform in men with metastatic castration-resistant prostate cancer (mCRPC) treated with an androgen receptor signalling inhibitor (ARSI).
To contain the spread of the COVID-19 pandemic, many countries around the globe have adopted social distancing measures. Yet, establishing the causal effect of non-pharmaceutical interventions (NPIs) is difficult because they do not occur arbitrarily.
Cancer-testis (CT) antigens were identified by their ability to elicit T- or B-cell immune responses in the autologous host. They are typically expressed in a wide variety of neoplasms and in normal adult tissues are restricted to testicular germ cells.
Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell carcinomas (ccRCC). To identify novel therapeutic approaches to targeting PBRM1-defective cancers, we used a series of orthogonal functional genomic screens that identified PARP and ATR inhibitors as being synthetic lethal […]
To assess whether patients with a large renal mass, treated by radical nephrectomy (RN), could have benefited from preoperative renal mass biopsy (RMB). The decision to perform partial nephrectomy (PN) for an organ-confined > 4 cm renal mass can be complex.
