Novel and Multimodality Management Strategies for Localized Upper Tract Urothelial Carcinoma

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Perioperative Chemotherapy and Targeted Therapy for Locally Advanced UTUC

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Genomics of Upper Tract Urothelial Carcinoma

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

The Science of Combination Therapy in Non-Muscle-Invasive Bladder Cancer (NMIBC)

(UroToday.com) The American Urological Association (AUA)’s Drug Development in non-muscle-invasive bladder cancer (NMIBC) From Scientific, Regulatory, Clinician, and Patient Perspectives virtual meeting featured a keynote lecture presentation by Dr. Adam Palmer discussing the science of combination therapy. Dr. Palmer notes that one of the limitations of monotherapy is tumor heterogeneity. Specifically, inter-patient heterogeneity suggests that monotherapy works […]

The Natural History of High-Risk NMIBC: Novel Therapies Versus Cystectomy

(UroToday.com) The clinical dilemmas in the management of non-muscle-invasive bladder cancer (NMIBC) session at the American Urological Association (AUA)’s Drug Development in NMIBC From Scientific, Regulatory, Clinician, and Patient Perspectives virtual meeting featured a presentation by Dr. Angela Smith discussing the natural history of high-risk NMIBC and novel therapies compared to radical cystectomy. High-risk NMIBC according […]

Sequential Therapy in BCG Unresponsive Disease

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Keynote: Racial Disparities in Bladder Cancer Clinical Trials

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

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