Trial Design Considerations for Intermediate Risk Non Muscle-Invasive Bladder Cancer

(UroToday.com) The AUA’s Drug Development in NMIBC From Scientific, Regulatory, Clinician, and Patient Perspectives virtual meeting session on clinical dilemmas in the management of non-muscle-invasive bladder cancer (NMIBC) included a discussion of clinical trial design considerations for intermediate-risk non-muscle-invasive bladder cancer (NMIBC) by Dr. Trinity Bivalacqua. 

ASCO GU 2021 bladder cancer – Anne Schuckman (Radical Cystectomy for High-Risk Non-Muscle-Invasive Bladder Cancer: Who and Why?)  – 2038

Ashish Kamat: Hello, and welcome to UroToday’s Bladder Cancer Center of Excellence, your one-stop destination for the latest developments in the field of bladder cancer. And along these lines, it’s my pleasure to welcome today, Professor Anne Schuckman, who is Assistant Professor and Director of Urologic Oncology at USC/Keck Department of Urology in Los Angeles, […]

ASCO GU 2021 bladder cancer – Ali Khaki (Abstracts 445, 444, 406) – advanced urothelial carcinoma – ####

Petros Grivas: Hello, I’m Dr. Petros Grivas. I’m a Medical Oncologist at the Seattle Cancer Care Alliance. I’m an Associate Professor of University of Washington, and Fred Hutchinson Cancer Research Center. I’m very excited today to host Dr. Ali Khaki, who’s an Assistant Professor at Stanford University. He was a MNT for our team here […]

What Novel Therapies Can Compete (or Combine) with BCG in BCG-naïve Non-Muscle Invasive Bladder Cancer (NMIBC)?

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Model Systems to Facilitate Development of Therapies for Non-Muscle-Invasive Bladder Cancer

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Regulatory Considerations in the BCG-Naïve Non-Muscle-Invasive Bladder Cancer Setting

(UroToday.com) Most patients newly diagnosed with bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with BCG is guideline-recommended on the basis of proven benefits in disease recurrence. While BCG is efficacious, many patients eventually develop BCG-unresponsive disease. For many years, there […]

Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

The efficacy and safety of nivolumab plus cabozantinib as compared with those of sunitinib in the treatment of previously untreated advanced renal-cell carcinoma are not known. In this phase 3, randomized, open-label trial, we randomly assigned adults with previously untreated clear-cell, advanced renal-cell carcinoma to receive either nivolumab (240 mg every 2 weeks) plus cabozantinib […]

A multiobserver study investigating the effectiveness of prostatic multiparametric magnetic resonance imaging to dose escalate corresponding histologic lesions using high-dose-rate brachytherapy.

Using multiparametric MRI data and the pathologic data from radical prostatectomy specimens, we simulated the treatment planning of dose-escalated high-dose-rate brachytherapy (HDR-BT) to the Multiparametric MRI dominant intraprostatic lesion (mpMRI-DIL) to compare the dose potentially delivered to the pathologically confirmed locations of the high-grade component of the cancer.

X