A research team led by Andrew Armstrong, MD, MSc, identifies new targets for treating non-clear cell renal carcinoma In 2016, a global multi-institutional team of investigators led by Duke Cancer Institute member and professor of Medicine, Surgery, Pharmacology and Cancer Biology, Andrew Armstrong, MD, MSc, reported in The Lancet their finding that a small-molecule drug (sunitinib) they’d trialed in patients […]
We determined whether a clinicopathological nomogram is able to predict the risk of pelvic lymph node metastasis (LNM) in penile cancer patients after inguinal lymph node dissection (ILND). Ninety-eight patients with bilateral ILND who underwent pelvic lymphadenectomy at 10 centers were retrospectively analyzed.
Tyrosine kinase inhibitors (TKI) and immunotherapy improved survival in metastatic renal cell carcinoma (mRCC). Disparities in treatment access are present in healthcare systems globally. The aim of this study was to analyze survival outcomes of mRCC patients treated with first-line TKIs in the public (PHS) and private (PrS) health system in a Brazilian Cancer Center.
Coffee consumption has been associated with a reduced risk of some cancers, but the evidence for renal cell carcinoma (RCC) is inconclusive. We investigated the relationship between coffee and RCC within a large cohort.
Intraductal (IDC) and cribriform (CRIB) histologies in prostate cancer have been associated with germline BRCA2 (gBRCA2) mutations in small retrospective series, leading to the recommendation of genetic testing for patients with IDC in the primary tumour.
Evaluation of the comparative effectiveness of enzalutamide and abiraterone in patients with metastatic castration-resistant prostate cancer (mCRPC) is limited to meta-analyses of randomized trials that exclude patients with significant comorbidities.
To determine whether multi-parametric magnetic resonance imaging (mpMRI) can reliably predict proximity of prostate cancer to the prostatic urethra in a contemporary series of men undergoing radical prostatectomy (RP) at two academic centers.
Restriction Spectrum Imaging (RSI-MRI) is a short duration enhanced diffusion weighted technique that seeks to standardize sequences and predict upgrading. We test this technology for active surveillance biopsies.
To describe the study design of the GÖTEBORG prostate cancer screening (PC) 2 (Göteborg-2), a prospective, randomised, population-based trial of PC screening. This trial evaluates whether prostate-specific antigen (PSA) testing followed by 3 Tesla prostate magnetic resonance imaging (MRI) and targeted biopsy can reduce overdiagnosis, while maintaining the detection of clinically significant cancer, compared to […]
Finasteride use has been associated with a reduced incidence of bladder cancer (BCa). However, the majority of studies have been conducted primarily in East Asian or Caucasian populations. Given differences in the incidence of BCa among racial/ethnic groups, it is important to determine whether the effect of finasteride use on BCa varies by race/ethnicity.
