MicroRNAs (miRNAs), a group of non-coding post-transcriptional regulators of gene expression, are dysregulated in clear cell renal cell carcinoma (ccRCC) and play an important role in carcinogenesis.
Longer follow-up and new trial data from phase 3 randomised controlled trials investigating immune checkpoint blockade (PD-1 or its ligand PD-L1) in advanced clear-cell renal cell carcinoma (RCC) have recently become available.
A paradigm shift in management of small renal masses has increased utilization of active surveillance. However, questions remain regarding safety and durability in younger patients. Patients aged 60 or younger at diagnosis were identified from the Delayed Intervention and Surveillance for Small Renal Masses registry.
Prior studies have demonstrated declines in androgen levels in men with cancer and patients undergoing anesthesia and surgery. In this study, we hypothesized that decreased serum androgen levels are prevalent in male patients undergoing radical cystectomy (RC) for bladder cancer and that it persists in the postoperative period.
We aimed to compare open versus robotic-assisted radical cystectomy (RARC) with intracorporeal ileal conduit (ICIC), versus RARC with extracorporeal ileal conduit (ECIC) formation for bladder cancer.
Penile squamous cell carcinoma (PSCC) is among the rarest genitourinary cancers, especially in high-income countries, nevertheless, it is burdened with poor survival outcomes.1 Among the risk factors associated with PSCC development, human papillomavirus (HPV) infection is the linchpin of the worldwide spread of this tumor.2, 3 Particularly, HPV DNA is identified in almost 50% of […]
In recent years, more studies have been dedicated to Peyronie’s disease (PD). However, data on PD incidence and prevalence likely underestimate the commonality of the condition, and even more, limited information is available on regional variations in diagnosis rates. In the United States, there are currently three population-based studies investigating the epidemiology of PD. All […]
Cisplatin-based chemotherapy is the preferred first-line for patients with metastatic urothelial cancer if they are cisplatin eligible. However, a significant proportion of these patients already receive cisplatin-based chemotherapy in the perioperative setting for their localized disease. It is unclear if re-challenge with platinum-based chemotherapy (PBC) is a better option compared to non-platinum based (NPBC) chemotherapy. […]
The primary aim of this retrospective multicenter analysis was to assess the performance of PSMA PET/CT using [18F]DCFPyL in the detection and localization of recurrent prostate cancer post radical prostatectomy (RP).
To assess the multiparametric MRI (mpMRI) appearances of normal peripheral zone (PZ) across age groups in a biopsy-naïve population, where prostate cancer (PCa) was subsequently excluded, and propose a scoring system for background PZ changes.
