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The aim of this study was to evaluate clinical features associated with benign histopathology of falsely classified Prostate Imaging Reporting and Data System (PI-RADS) category 4 and 5 lesions. Between March 2015 and November 2020, 1161 patients underwent mpMRI/Ultrasound-fusion-guided prostate biopsy (FBx) and concurrent 12-core systematic prostate biopsy (SBx) at the Department of Urology of […]

Risk classification of primary prostate cancer in clinical routine is mainly based on prostate-specific antigen (PSA) levels, Gleason scores from biopsy samples, and tumor-nodes-metastasis (TNM) staging.

Penile cancer (PC) is a typical tumor of non-industrialized countries. The incidence is 20-30 times higher in Africa and South America, considering the elevated prevalence of sexually transmitted diseases.

For muscle-invasive bladder cancer, bladder preserving chemoradiotherapy (BPCRT) has shown to be a viable alternative for patients with urothelial carcinoma (UCa). Traditionally bladder cancer with variant histology UCa or other tumors types involving the bladder have worse outcomes and BPCRT has been contraindicated.

To investigate the association between Ki67 index and programmed death-ligand 1 (PD-L1) expression in muscle-invasive bladder cancer (MIBC) patients after RC. We retrospectively evaluated 262 MIBC patients treated with RC between April 2004 and April 2020.

Growing evidence supports the pivotal role of long non-coding RNAs (lncRNAs) in the regulation of cancer development and progression. Their expression patterns and biological function in muscle invasive bladder cancer (MIBC) remain elusive.

Molecular subtyping has become increasingly important in bladder cancer, and it is mainly divided into "luminal" and "basal" types. Despite the large amount of studies about the molecular pathway of bladder cancer, there are few studies about BAP-1.

Germ cell tumors (GCT) are the most common testicular neoplasms seen mainly in young adults. Although a range of extragonadal tissues can be involved, the most frequent site of metastasis is the retroperitoneal lymph nodes. A ‘burned-out’ testicular tumor is a well-documented phenomenon in which the primary tumor has spontaneously regressed, often with only a […]

Theranostic methods are changing the standard of care in men with prostate cancer. By enabling targeted imaging and therapy, agents targeting prostate-specific membrane antigen (PSMA) enable both detection and subsequent treatment of recurrent or metastatic prostate cancer. However, a significant fraction of prostate tumors demonstrates heterogeneous, low, or absent expression of PSMA. CD46 is a […]

Unequivocal clinical progression (UCP)-a worsening of clinical status with or without radiographic progression (RAD)-represents a distinct mode of disease progression in metastatic prostate cancer. We evaluated the prevalence, risk factors and the impact of UCP on survival outcomes.