Capivasertib is a pan-AKT inhibitor. Preclinical data indicate activity in metastatic castration-resistant prostate cancer (mCRPC) and synergism with docetaxel. ProCAID was a placebo controlled randomized phase II trial in mCRPC.
Penile squamous cell carcinoma (PSCC) is a rare cancer, with approximately 2000 new cases in the United States and 35,000 globally every year. Multiple risk factors are involved in PSCC, but most importantly, the high-risk human papillomavirus infection is thought to be present in approximately 50% of cases.
Intraoperative hypothermia (IOH) has been suggested to adversely impact outcomes following surgery. The objective of this study was to evaluate the association between IOH and survival following radical cystectomy (RC).
BCG immunotherapy has shown significant success for bladder cancer treatment, but due to the complexity of the interaction between immunity and cancer, clinical outcomes vary significantly between patients.
Prognosis for patients with metastatic bladder carcinoma (mBC) remains limited and in need of novel therapies. We retrospectively analyzed medical records of 43 patients with platinum-refractory metastatic bladder cancer (mBC) who participated in one or more phase 1 trials of various investigational therapies.
The therapeutic landscape of metastatic urothelial carcinoma (mUC) becomes increasingly dense: standard therapy remains cisplatin-based chemotherapy, followed by immunotherapy with checkpoint inhibitors as maintenance or second-line.
Life expectancy (LE) for patients presenting with newly diagnosed renal cell carcinoma (RCC) is often lower compared to the normal population irrespective of RCC. This observation has prompted the diffusion of active surveillance as a reasonable option in cases with limited LE and features of non-aggressive disease to reduce overtreatment. On the other hand, radical […]
Penile curvature can be considered a rare disease, conditioning significant psychological stress for patients. Once medical treatment fails, surgery is the standard of choice. Technically, circumcision is usually combined with penile degloving in order to reduce the risk of postoperative edema and, consequently, phimosis and necrosis.
Through the collaborative efforts of the EAU Section of Infections in Urology (ESIU) and the German Medical Science (GMS), a “living textbook” came to fruition. The newly-published “Urogenital Infections and Inflammations” is an open-access book which is continually updated with the latest developments, literature synthesis per topic, recommendations based on levels of evidence for contemporary […]
Pathological risk factors for metastatic disease in patients with testicular non-seminomatous germ cell tumors are debated. The tumor-node-metastasis (TNM) classification eighth edition for testicular cancers includes divergent versions, by the International Union Against Cancer (UICC) and by the American Joint Committee for cancer (AJCC).
