SUO 2020: Significant Anti-Adenovirus Antibody Response Positively Correlates with Efficacy in Patients Treated with Nadofaragene Firadenovec for High-Grade Bacillus Calmette Guerin (BCG)-Unresponsive Non Muscle Invasive Bladder Cancer (NMIBC)

(UroToday.com) Nadofaragene firadenovec is a non-replicating recombinant type-5 adenovirus vector-based gene therapy that delivers a copy of the human IFNα2b gene. Adenoviruses provide short-term, high but transient expression of the gene of interest in a relatively broad range of host cells. The Phase III trial of nadofaragene firadenovec for Bacillus Calmette Guerin (BCG) unresponsive on muscle […]

SUO 2020: Low Rate of Cystectomy and Delayed Median Time to Cystectomy Among Patients Who Achieved Complete Response with Nadofaragene Firadenovec

(UroToday.com) Most patients with newly diagnosed bladder cancer have non-muscle invasive disease (NMIBC). For patients with intermediate or high-risk NMIBC and those with carcinoma in situ (CIS), adjuvant treatment with Bacillus Calmette Guerin (BCG) is recommended by many guideline bodies due to proven benefits in disease recurrence. For patients who become BCG-unresponsive, there have been very limited […]

SUO 2020: Subgroup Analyses of the Phase 3 Study of Intravesical Nadofaragene Firadenovec in Patients with High-Grade, Bacillus Calmette Guerin (BCG)-Unresponsive Non Muscle Invasive Bladder Cancer (NMIBC)

(UroToday.com) The goals of treatment of non muscle invasive bladder cancer (NMIBC) are to reduce recurrence and prevent progression, however, despite optimal treatment, ≥50% of patients who demonstrated an initial response to Bacillus Calmette Guerin (BCG) will experience recurrence and progression and become BCG-unresponsive. With limited treatment options, there is an unmet medical need for local, effective, […]

Prognostic capabilities and clinical utility of cell cycle progression testing, prostate imaging reporting and data system, version 2, and clinicopathologic data in management of localized prostate cancer.

To compare the prognostic capabilities and clinical utility of the cell cycle progression (CCP) gene expression classifier test, multiparametric magnetic resonance imaging (mpMRI) with Prostate Imaging Reporting and Data System (PI-RADS) scoring, and clinicopathologic data in select prostate cancer (PCa) medical management scenarios.

SUO 2020: Increasing Enrollment of Underrepresented Populations in Clinical Trials

(UroToday.com) In conjunction with this year’s virtual annual meeting, the Society of Urologic Oncology, in conjunction with the Young Urologic Oncologists (YUO), convened a Symposium on Clinical Research and Clinical Trials. In this context, Dr. Tracy Downs presented arguably one of the most important talks of the day, examining efforts to increase the enrollment of under-represented […]

SUO 2020: Young Urologic Oncologists Paper of the Year Presentation: Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy – The PREVENTER Randomized Clinical Trial

(UroToday.com) The 2020 Young Urologic Oncologists paper of the year was awarded to Dr. Hiten Patel for his publication “Effect of Pharmacologic Prophylaxis on Venous Thromboembolism After Radical Prostatectomy: The PREVENTER Randomized Clinical Trial” published earlier this year in European Urology.1

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