Understanding urologic scientific publication patterns and general public interests on stone disease: lessons learned from big data platforms.

To analyse patterns of stone disease online information-seeking behaviours in the United States and to correlate with urological literature publication aspects. To compare Relative Search Volume (RSV) among different twelve preselected urologic keywords we chose "United States" as country and "01/01/2009-31/12/2018" as time range on Google Trends (GT).

Predictive value of preoperative comprehensive evaluation on the efficacy of HoLEP.

With the aging of the population, prostate hyperplasia is more and more perplexing to the old men. This study aimed to evaluate the predictive value of international prostatic symptom score-voiding/storage score ratio (IPSS-V/S), urodynamic examination, intravesical prostatic protrusion (IPP) and residual urine volume (RUV) on the efficacy of holmium laser enucleation of the prostate (HoLEP) […]

Assessing the outcome of Holmium Laser Enucleation of the Prostate (HoLEP) by age, prostate volume, and a history of blood thinning agents – report from a single-center series of >1,800 consecutive cases.

To assess perioperative outcomes of HoLEP in a real-world scenario and with a focus on demanding patient factors such as large prostate size, advanced patient age, and anticoagulation therapy (AT). We retrospectively analysed HoLEP procedures at our institution between 2010-2016.

[Single-center study of the abnormal concentration of bone imaging agent and prostate cancer bone metastasis prediction model].

Objective: To investigate the relationship between total prostate specific antigen (TPSA), free prostate specific antigen/total prostate specific antigen [RAT (F/T)], Gleason score, other factors and the whole-body bone plane imaging which was used to evaluate the bone metastasis of prostate cancer (PCa), and the diagnostic value of the abnormal concentration of bone imaging agent for […]

Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation to drive aggressive prostate cancer to the bone.

Metabolic dysregulation is a known hallmark of cancer progression, yet the oncogenic signals that promote metabolic adaptations to drive metastatic cancer remain unclear. Here we show that transcriptional repression of mitochondrial deacetylase sirtuin 3 (SIRT3) by androgen receptor (AR) and its coregulator steroid receptor coactivator (SRC-2) enhances mitochondrial aconitase (ACO2) activity to favor aggressive prostate […]

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