Our previous presurgical weight loss trial among 40 prostate cancer patients found that rapid (but not slow) weight loss resulted in increased tumor Ki67 and Cathepsin L (CTSL) gene expression. In follow-up analyses, we strove to better understand these unexpected findings.
Penile squamous cell carcinoma (PSCC) represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation.
APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C.
Bladder cancer prognosis is closely linked to the underlying differentiation state of the tumor, ranging from the less aggressive and most-differentiated luminal tumors to the more aggressive and least-differentiated basal tumors.
Non-muscle invasive bladder cancer (NMIBC), which is characterized by a recurrence rate of approximately 30% and very long treatment times, remains a major unresolved problem for patients and the health care system.
In patients with haematuria, a fast, noninvasive test with high sensitivity (SN) and negative predictive value (NPV), which is able to detect or exclude bladder cancer (BC), is needed. A newly developed urine assay, Xpert Bladder Cancer Detection (Xpert), measures five mRNA targets (ABL1, CRH, IGF2, UPK1B, and ANXA10) that are frequently overexpressed in BC.
Stress urinary incontinence (SUI) is a common condition affecting up to 50% of women in developed countries, with the risk of requiring surgery of about 4%.1,2 Surgical treatment is indicated when conservative management fails.3 Many types of surgery have been performed over the years. To date, mid-urethral slings are considered the first option because of high […]
San Francisco, California (UroToday.com) — Like many healthcare practices, the COVID-19 pandemic has revolutionized the way Urology of St. Louis (USL) offers care to their patients. Within weeks after the pandemic started, USL, which has fifteen locations in the Metro East and St. Louis, created and rapidly adopted a virtual platform which allows all thirty […]
Charles Ryan: Hello, I am joined today by Dr. Brandon Mahal who’s an Assistant Professor of Radiation Oncology at the University of Miami, where he’s also an Assistant Director of the cancer center there for community outreach and engagement. He published a really interesting letter in the New England Journal of Medicine recently that puts […]
Alicia Morgans: Hi, my name is Alicia Morgans and I’m a GU Medical Oncologist and Associate Professor of Medicine at Northwestern University. Thank you so much for being here with me today, Dr. Pedro Barata, who is an Assistant Professor of Medicine at Tulane University, GU medical oncologist, who has recently published a really informative […]
