The aim of this study is to investigate the potential impact of prostate magnetic resonance imaging (MRI) -related interreader variability on a population-based randomized prostate cancer screening trial (ProScreen).
Patients with high-risk prostate cancer are at increased risk of lymph node metastasis and are thought to benefit from whole pelvis radiotherapy (WPRT). There has been recent interest in the use of hypofractionated radiotherapy in treating prostate cancer.
Inflammation and tumorigenesis are related. We conducted this study to evaluate whether inflammatory factors (IFs) have a diagnostic value for pathology and a predictive value for survival and recurrence in bladder cancer patients undergoing total cystectomy.
To evaluate the role of the Vesical Imaging-Reporting and Data System (VI-RADS) score in the diagnostic pathway of bladder cancer. A systemic search of the contemporary literature was performed in December 2019 using the Medical Literature Analysis and Retrieval System Online (MEDLINE), the Excerpta Medica dataBASE (EMBASE), and Web of Science databases focussing on all […]
Nitroxoline is considered to be an effective treatment for the urinary tract infections. Recently, it has been found to be effective against several cancers. However, few studies have examined the anti-tumor activity of nitroxoline in bladder cancer.
Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers.
(UroToday.com) Given the recent large efforts to molecularly subclassify bladder cancer, there has been a growing emphasis to ensure external validation and appropriate classification. Researchers from Lund University, Sweden, used bioinformatics tools including rule-based and centroid based algorithms in an attempt to identify methods that can reproducibly classify a newly profiled bladder tumor samples in a […]
(UroToday.com) Molecular players in bladder tumor microenvironment were investigated by researchers from Uppsala University who performed targeted protein biomarker analysis using a multiplexed assay on plasma and urine samples from patients with bladder cancer.
(UroToday.com) Investigators from Erasmus University Medical Center, The Netherlands, presented their analysis of high-throughput genomic profiling of biopsies from patients with metastatic urothelial carcinoma. Using whole-genome DNA sequencing and RNAseq analyses, they provided a comprehensive overview of alterations in metastatic bladder cancer.
(UroToday.com) Several virtual posters presented at the Translational Track session added to the growing body of evidence that tumor microenvironment influences the behavior of bladder cancer and can impact response to therapies.
