Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters will help to identify patients with unexplained and male factor infertility who may have seminal oxidative stress and determine if ORP testing is needed.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, which 50% of men are infected at some point in their lives. Type III CP/CPPS is the most complex and controversial of all types of prostatitis, the highest incidence rate, uncertain efficacy, the long-term treatment that affects the patient’s psychopathic […]
penile curvature is a rare condition, classified as congenital or acquired (Peyronie’s disease) (PD). Surgical correction is the standard treatment. It’s common practice to associate circumcision with penile de-gloving to prevent complications.
Thulium lasers operate at wavelengths between1940-2013 nm either in a continuous wave or in a pulsed mode, which enables smooth incisions with fast vaporization or effective laser lithotripsy for urolithiasis.
To evaluate the association between non-neurogenic lower urinary tract symptoms (LUTS) and frailty among treatment-seeking older men. This is a cross-sectional study of male patients age 65 years and older presenting to an academic urology practice between December 2015 and March 2019.
(UroToday.com) STAG2, part of cohesin, a complex involved in chromosome organization and DNA repair, has been described as a tumor suppressor gene in bladder cancer.1 While the mechanisms by which STAG2 contributes to bladder carcinogenesis have not been clearly elucidated, it has been proposed that they involve processes different from altered chromosome segregation. STAG2 inactivation is […]
(UroToday.com) Genomic characterization of bladder carcinoma in situ (CIS) mostly has been in the context of concurrent papillary tumors, and not necessarily unique CIS. Dr. Noah Hahn presented results investigating the feasibility of obtaining high-quality transcriptome data from CIS specimens utilizing the novel extraction-free EdgeSeq Precision Immuno-Oncology Panel (PIP) platform.
(UroToday.com) APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations within the same gene in bladder cancer. However, only a few APOBEC-associated driver hotspot mutations have been identified in bladder cancer. Dr. Shi and colleagues from Institut Curie, Paris, present an effort to systematically […]
(UroToday.com) Neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy has been shown to improve survival in patients with muscle-invasive bladder cancer. However, nearly 60% of patients are inherently resistant to neoadjuvant chemotherapy at the time of cystectomy. While several mechanisms of cellular resistance to cisplatin have been proposed, these do not offer any effective patient response […]
(UroToday.com) Dr. Kerzeli presented work by her and colleagues from Uppsala University, Sweden, where they induced and profiled an autochthonous bladder cancer model in an effort to improve understanding of bladder tumor development and progression in the native microenvironment.
