IBCN 2020: Cabozantinib Plus Durvalumab in Patients with Advanced Urothelial Carcinoma After Platinum Chemotherapy: Phase 2 ARCADIA Trial

(UroToday.com) Dr. Laura Marandino, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy presented “Cabozantinib plus durvalumab in patients with advanced urothelial carcinoma after platinum chemotherapy: safety and preliminary activity of the open-label, single-arm, phase 2 ARCADIA trial.”  As single agents, both durvalumab and cabozantinib have efficacy in advanced urothelial carcinoma. 

IBCN 2020: Transition of ANX10 Expression Is a Useful Diagnostic and Prognostic Marker in Upper Tract Urothelial Carcinoma

(UroToday.com) Dr. Tetsutaro Hayashi, Hiroshima University Department of Urology, Hiroshima, Japan presented “Transition of ANX10 expression is a useful diagnostic and prognostic marker in upper tract urothelial carcinoma (UTUC).”  There exists a relative paucity of informative biomarkers for UTUC compared to bladder urothelial carcinoma.  Dr. Hayashi et al. investigated ANXA10 as a potential biomarker for […]

IBCN 2020: Correlation between BMI, Diabetes Mellitus, and Outcomes in Patients Treated with BCG Immunotherapy for Non Muscle-Invasive Bladder Cancer

(UroToday.com) Dr. Nathan Brooks, Society of Urologic Oncology (SUO) Fellow at the MD Anderson Cancer Center, Houston, Texas, USA presented “Correlation Between Body Mass Index (BMI), diabetes mellitus (DM), and Outcomes in Patients Treated with Bacillus Calmette Guerin (BCG) Immunotherapy for non-muscle-invasive bladder cancer (NMIBC).”  An ‘obesity paradox’ exists in a number of malignancies, characterized by generally […]

IBCN 2020: Age is Associated with Response to Immune Checkpoint Blockade in Advanced Urothelial Carcinoma

(UroToday.com) Dr. Wolfgang Beck, University of North Carolina, Chapel Hill, North Carolina, USA presented “Age is associated with response to immune checkpoint blockade in advanced urothelial carcinoma.”  The investigators performed post hoc analysis on IMvigor210 data and identified an age cutoff point of 72 years, with older patients achieving a relatively better response than younger patients.  […]

IBCN 2020: The Role of Blue Light Cystoscopy in Detecting Invasive Bladder Tumors: Data from Multi-institutional Registry

(UroToday.com) Dr. Hamed Ahmadi, Society of Urologic Oncology (SUO) Fellow at the University of Southern California, Los Angeles, California, USA presented “The Role of Blue Light Cystoscopy in Detecting Invasive Bladder Tumors: Data from Multi-institutional Registry.”  While Blue Light cystoscopy (BLC) has a defined role in non-muscle-invasive bladder cancer (NMIBC), with increase detection and decreased recurrence […]

IBCN 2020: The Impact of Upper Tract Urothelial Carcinoma (UTUC) on Outcomes of Non-Muscle-Invasive Bladder Cancer Treated with Intravesical BCG

(UroToday.com) Dr. Kelly Bree, Society of Urologic Oncology (SUO) Fellow at the MD Anderson Cancer Center, Houston, Texas presented “Impact of upper tract urothelial carcinoma (UTUC) on Outcomes of NMIBC Treated with Intravesical Bacillus Calmette Guerin (BCG) .”  Little is known about the role of UTUC on contemporary intravesical BCG outcomes for non-muscle-invasive bladder cancer (NMIBC). 

IBCN 2020 Specific Genetic Susceptibility Patterns of the Urothelial bladder Cancer Taxonomic Subtypes

(UroToday.com) Dr. Raquel Benitez Dorta, Spanish National Cancer Research Centre, Madrid, Spain presented “Specific Genetic Susceptibility Patterns of the Urothelial bladder Cancer Taxonomic Subtypes.”  Dr. Dorta et al. investigated an immunohistochemical phenotype in bladder tumors consisting of KRT14, FOXA1, and GATA3, and correlated expression of these markers with germline DNA variants.  

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