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(UroToday.com) Since 2015, multiple studies together have suggested that approximately a quarter of metastatic castration-resistant prostate cancer (mCRPC) tumors have mutations in DNA damage repair (DDR) genes. These alterations, especially those in genes for homologous recombination repair (HRR), are associated to varying degrees with response to PARP inhibitor therapy. Two PARP inhibitors are now approved […]

(UroToday.com) Docetaxel is an approved therapy for the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) that may work in part by inducing immunogenic cell death of prostate cancer cells. The KEYNOTE-365 study (NCT02861573) tested this hypothesis in its cohort B arm with a study of standard dosing pembrolizumab and docetaxel with prednisone 5 mg […]

(UroToday.com) High-risk localized prostate cancer is managed with either surgery, or the combination of radiation therapy plus androgen deprivation therapy (ADT). Despite treatment with curative intent, approximately half of patients experience recurrence, with significant prostate cancer specific mortality. The NADIR trial aims to test the hypothesis that the addition of PARP inhibition to definitive radiotherapy plus […]

(UroToday.com) Patients with high-risk localized prostate cancer who receive radiotherapy for management of their primary disease also receive LHRH analog therapy for at least one year or longer. Patients who undergo surgery for their localized prostate cancer but have persistent PSA and high-risk features such as lymph node involvement also undergo adjuvant radiation combined with LHRH […]

(UroToday.com) Non-clear cell renal carcinomas comprised approximately 25% of all renal cell carcinomas (RCC), and are notable for heterogeneous histologies, limited treatment options and worse outcomes relative to clear-cell RCC. Cabozantinib is a tyrosine kinase inhibitor (TKI) that impacts the TAM kinases (TYRO3, AXL, MER), VEGFR2, and MET, with the cumulative effects shown in the figure […]

(UroToday.com) The CheckMate 032 (NCT01928394) study is a multicenter open label phase ½ trial examining the efficacy of the anti-PD1 antibody nivolumab as monotherapy or in combination with the anti-CTLA4 antibody ipilimumab in several advanced tumor setting. The schema of the study is shown below:

(UroToday.com) Molecular characterization of bladder cancer by gene expression profiling has generated disease subtypes that are associated with response to neoadjuvant therapy in muscle-invasive bladder cancer. Post-treatment residual disease appears to undergo changes in molecular profile, characterized recently by a publication1 into four expression profile clusters: CC1 (basal), CC2 (Luminal), CC3 (Immune) and CC4 (Scar-like). These […]

(UroToday.com) Clinical trials of immune checkpoint blockade (ICB) historically exclude patients with pre-existing autoimmune diseases because of concerns around decreased efficacy due to immunosuppression as well as toxicity. Real-world evidence suggests that immune-related adverse events associated with immune checkpoint blockade are manageable in patients with pre-existing autoimmune disease. In this presentation, Dr. Hoffman-Censits and colleagues present […]

(UroToday.com) Platinum based chemotherapy is the mainstay of first-line treatment for medically eligible patients with advanced urothelial carcinoma. Unfortunately, up to 50% of patients are unable to receive cisplatin, and disease progression often develops even for patients who receive cisplatin. Immunotherapy with checkpoint blockade are a standard of care option for platinum-ineligible patients or those who […]

(UroToday.com) Platinum-based chemotherapy is the mainstay of first-line treatment for medically eligible patients with advanced urothelial carcinoma (UC). Unfortunately, up to 50% of patients are unable to receive cisplatin, and disease progression often develops even for patients who receive cisplatin. Immunotherapy with checkpoint blockade is a standard of care option for platinum-ineligible patients or those who […]