Androgen-receptor (AR) inhibition can upregulate c-MET expression, which may be a resistance mechanism driving progression of castration-resistant prostate cancer (CRPC). We conducted a phase 1 trial investigating the safety and pharmacokinetics of a potent c-MET inhibitor crizotinib with the AR antagonist enzalutamide in CRPC.
For biopsies with Gleason 3 + 3 = 6 or 3 + 4 = 7 prostate cancer, the Genomic Prostate Score (GPS; OncotypeDx) is designed to predict severe pathology at prostatectomy, and, in some cases, recommends reclassification of the National Comprehensive Cancer Network (NCCN) risk category.
Prostate cancer is one of the most common and socially significant cancers among men. The aim of our study was to reveal changes in miRNA expression profiles associated with lymphatic dissemination in prostate cancer and to identify the most prominent miRNAs as potential prognostic markers for future studies.
The primary treatment for localized renal cell carcinoma (RCC) is surgical resection with curative intent. Despite this, many patients, especially those with high-risk features, will develop recurrent or metastatic disease.
Maranhão State-Northeast Brazil-has the world’s highest incidence of penile cancer. This study describes the epidemiological, histopathological and clinical profile of patients stricken across that Brazilian state.
Treatment of advanced urothelial carcinoma (UC) remains a challenging clinical entity occurring predominantly in older patients with limited treatment options. However, real-world treatment patterns, differential cancer center access, and association with outcomes is lacking in nationally representative clinical practice and will provide context for emerging therapies.
To evaluate the pharmacology, pharmacokinetics, clinical efficacy, safety, dosing, cost, and clinical implications of enfortumab vedotin-ejfv (EV) in the treatment of locally advanced or metastatic urothelial carcinoma (UC).
Cystoscopy plays an important role in the diagnosis of bladder tumors. As a typical representative of the deep learning algorithm, the convolutional neural network has shown great advantages in the field of image recognition and segmentation.
There have been concerns about higher incidence of local and retroperitoneal recurrences after robot-assisted radical cystectomy (RARC) compared to open radical cystectomy. We sought to report and detail relapses following RARC utilizing a multinational database.
(UroToday.com) Penile cancer is a rare genitourinary malignancy, affecting less than 1 in 100,000 patients in Western industrialized countries. Platinum chemotherapy is the mainstay of treatment for metastatic penile cancer (disease that has spread outside the pelvis), but unfortunately, disease control is poor, and overall survival in the metastatic setting is typically less than 1 year. […]
