Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma.

Alterations in fibroblast growth factor receptor 3 (FGFR3) occur in ∼15% of muscle-invasive bladder cancers (MIBCs) and metastatic urothelial carcinomas (mUCs). To determine the association between FGFR3 status and response to platinum-based chemotherapy in patients with MIBC or mUC.

Comparison of 68Ga-PSMA-I/T PET-CT and Multiparametric MRI for Locoregional Staging of Prostate Cancer Patients: A Pilot Study.

The objective of this work was to assess the value of 68Ga-DOTAGA-(3-iodo-y)fk(Sub-KuE) positron emission tomography (68Ga-PSMA-I/T PET-CT) and multiparametric magnetic resonance imaging (mp-MRI) for preoperative staging in prostate cancer (PCa) patients who underwent radical prostatectomy (RP) by validating with postoperative histopathology data.

Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC

(UroToday.com) In conjunction with the Scientific Congress held as part of the American Society of Clinical Oncology’s (ASCO) Annual Meeting in May 2020, an Educational Symposium was convened on August 8 to 10th. In a session entitled “Sorting Through the Maze of Treatment Options for Metastatic Castration-Sensitive Prostate Cancer”, Dr. Alicia Morgans from Northwestern University […]

Sequencing and Combining Targeted and Immunotherapy

(UroToday.com) The 2020 American Society of Clinical Oncologists (ASCO) virtual education program featured a session on the evolution of renal cell carcinoma (RCC) treatment, including a presentation by Dr. Jaleh Fallah from the Cleveland Clinic discussing sequencing and combining targeted and immunotherapy. Over the last couple of years, trials have utilized combination therapy to continue improving […]

The Beginnings of Immunotherapy for Renal Cell Carcinoma

(UroToday.com) At the ASCO 2020 virtual education program, Janice Dutcher, MD, discussed the beginnings of immunotherapy for renal cell carcinoma (RCC) as part of the evolution of RCC treatment session of talks. Cytokines are endogenous substances within the immune system and are responsible for cell signaling, as well as induction or inhibition of various cell regulatory […]

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