BCANTT 2020: High-Risk Non-Muscle Invasive BCG Unresponsive Bladder Cancer: Immune Response to BCG

(UroToday.com) Max Kates, MD, Johns Hopkins Greenberg Bladder Cancer Institute, presented mechanisms of bacillus calmette-guerin (BCG) in bladder cancer. T cell expansion is a driving force in immune cell recruitment. The immune checkpoint and BCG response has showed PDL1 expression is relatively high among patients with carcinoma in situ (CIS). Colonization of PDL1 and CD8 among BCG […]

BCANTT 2020: Phase 3 Trial of Nadofaragene Firadenovec for High-Risk, BCG Unresponsive, Non-Muscle Invasive Bladder Cancer

(UroToday.com) Colin Dinney, MD, of the MD Anderson Cancer Center, discussed Nadofaragene firadenovec. He reported the initial results of 30% complete response (CR) which prompted a phase III trial for bacillus Calmette-Guerin (BCG) unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC). A total of 157 patients were evaluated for safety with 151 patients for efficacy. At 3mo 53% […]

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