Coronaviruses (CoV) are a group of viruses whose antigens are expressed on their membranes in a characteristic “crown like” appearance, hence giving them their name (from Latin corona [crown]). Since their initial discovery in 1965,1 about 46 species have been identified in animals and humans with 2 species, namely, severe acute respiratory syndrome (SARS)-CoV-1 and Middle Eastern Respiratory Syndrome (MERS)-CoV receiving a great deal of attention due to their high rate of transmission and mortality.2 In December 2019, a novel strain of CoV emerged in the city of Wuhan, China and was termed SARS-CoV-2 as it had an 80% genetic similarity with the SARS-CoV-1 virus.3 This new infection which was also named COVID-19, based on the year of its appearance, rapidly spread throughout the world and was announced as a global pandemic on 11 March 2020. The SARS-CoV-2 virus is an RNS virus that belongs to the β-CoV subgroup and is characterized by having spike (S) proteins which facilitate viral cell entry, membrane (M) proteins and envelope (E) proteins which assist in viral assembly, and nucleocapsid (N) proteins which mediate viral transcription.4 The SARS-CoV-2 S protein undergo proteolytic priming by transmembrane protease, serine 2 (TMPRSS2) and gain access into host cells through the angiotensin-converting enzyme 2 (ACE2) receptor (Figure 1).5

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